DOI: 10.36347/sajb.2018.v06i03.009

Pages: 286-292

AMH is a biomarker for PCOD which has the potential to be used as a single marker for diagnosis, assessing disease severity and following treatment and IVF therapy. This study is designed to study the levels of AMH and factors affecting it in PCOD patients attending our hospital located in a rural area of Haryana. This study also will help generate data on AMH levels in healthy females specific to our laboratory and population. The case control study was conducted in the department of Biochemistry & Obstetrics & Genecology, BPS Govt Medical College for Women, Khanpur Kalan. 50 females in the age group 18 – 40 years diagnosed with polycystic ovarian disorder were taken as study group. 50 age matched healthy females (18-40 years age) were included as controls. BMI and waist circumference of PCOD patients was significantly higher than control group (p<0.001). Values of fasting blood sugar and HbA1c were significantly higher in study than in control group subjects (p<0.001). Values of triglycerides, total cholesterol, LDL-cholesterol were significantly higher in study than in control group subjects (p<0.001). Levels of HDL-Cholesterol were significantly lower in PCOD patients (p<0.001). The prevalence of dyslipidemia was significantly higher in study group than control group for all lipid parameters. AMH levels are significantly higher in PCOD patients (12.0±8.93 vs 5.35±1.80 ng/mL, p<0.001). Area under ROC curve for AMH was 0.766 with p <0.001. A cut-off of 7.1 ng/mL yielded 64.6% sensitivity and 89.8 % specificity for PCOD. AMH levels correlated with HbA1c (r=0.261, p<0.001) in PCOD patients. OCP use or obesity did not affect AMH levels in cases or controls. Oral Contraceptives were used by 54% patients and 46% healthy controls. PCOD patients had higher BMI and waist circumference. HbA1c and lipid profile was deranged in PCOD patients.........