DOI: 10.36347/sajb.2015.v03i02.018

Pages: 222-230

Cold atmospheric plasma (CAP) is a semi-ionizing gas with ions, electrons, and particles without charge such as atoms. CAP is produced by different methods such as atmospheric plasma jet (APPJ), pencil plasma and needle plasma. Today, the CAP along with other methods of cancer treatment used to in oncology. This study provides some information about the structure, different methods of production and the general mechanisms of cold atmospheric plasma. Furthermore, this study explores and interprets the results of studies done about the influence of cold atmospheric Plasma on cancer cells. Articles express investigated the relationship between cold atmospheric plasma and improved outcomes of cancer treatment. Cold atmospheric plasma through mechanisms such as activating protein P53, enabling inhibitor P21CDK, stop the cell cycle in phase G2 / M phase and S, stimulate apoptosis through ROS production and disable the mitochondria and so on, leading to tumor cell death. So it can be as a good therapy method is effective in destroying cancer cells. Case studies have shown that the use of cold atmospheric plasma in treatment of cancer patients, Not only will quickly eradicate tumors, but increases the median survival in patients. Moreover, the exact mechanism of cold atmospheric plasma action is still unknown that can be the subject of future research.