QSAR analysis on a set of synthesized 1H-indole-2, 3-dione Analogues tested fir growth inhibitory anticancer activity was performed by using MLR procedure. The activity contributions of these compounds were determined from regression equation and the validation procedures to analyze the predictive ability of QSAR models were described. .The results are discussed on the basis of statistical data. High agreement between experimental and predicted anticancer activity inhibitory values is obtained. The results of this study indicate that the substitution of electron withdrawing group, aromatic ring, polarizablity, etc. parameters has a significant effect on anticancer activity of this class of compounds, thus simplifying design of new biological active molecule.

Presently medical students must memorise numerous detailed facts about drugs and pharmacologically active substances without a direct clinical context. There is a need to encourage application of the knowledge to real-life scenarios, foster safe practice and enhance the confidence in treating clinical patients who are taking multiple medications. Facilitated teaching should be promoted instead of factual teaching which is routinely practiced in India. Learning involves a change in the learner’s behaviour. Problem-based learning (PBL) promotes integration of knowledge and fosters a deeper approach to life-long learning. There is a lacuna of PBL teaching in the Department of pharmacology in our college. Introduction of PBL will be an innovative effort in this regard. Aim of the study is to determine the levels of learning achieved by the learners as a result of the intervention viz., PBL and conventional Lecture Based Learning (LBL) and efficacy of the teaching and learning method in achieving the learning objectives/outcomes in pharmacology subject. Present study involves true experimental design and Randomised, Controlled study. Two groups consisting of second MBBS students (sample) will be exposed to conventional LBL (active control group) and PBL. Pre and post test (by using M.C.Qs) and attitude/feedback tests (by using Likert’s-type questions/items) will be conducted.Clinical application of knowledge will be assessed. Data will be collected and analyzed by using standard statistical tests (p<0.05). PBL may be used as an adjunct to or as a replacement for conventional LBL in pharmacology. Accordingly, modifications will be done in the curriculum (syllabus) of the University.

Patient counseling is an integral part of community pharmacy practice. It is an important service which helps improve the knowledge and understanding of patients on drugs requiring longer duration of regimen. This is particularly important in tuberculosis (TB) control where lack of knowledge and understanding can lead to drug resistance. The study aimed to measure the frequency of verbal counseling in community pharmacy and to determine the types of information provided. Three phases were done in 89 randomly selected community pharmacies. The first phase was face-to-face counseling of simulated patient (SP) with prescription, second was telephone counseling and the last phase was survey questionnaire using an 11-point likert scale which measured the practices of community pharmacists in patient counseling. During Phase I, most of the pharmacists and staff provided insufficient information on anti-TB drugs. In Phase II, some pharmacists provided only little information needed by the SP. In Phase III, a mean of 6.15, interpreted as “satisfactory” showed that pharmacists and staff provided counseling on anti-TB drugs but was limited to common information like name of the medication, indication and the dosage of the drugs. The results of the study suggest that good counselling practices on anti-TB drugs should be improved.

Medication errors are considered to be serious threats to patient’s safety. Effective medication error reporting is a necessary tool to prevent and reduce its occurrence. This study was conducted to determine and compare the knowledge, attitude and practices (KAPs) on medication error reporting among health practitioners from hospitals in Manila. 180 health practitioners, consisting of physicians, nurses and pharmacists were included in the study. Comparison between their knowledge, attitude and practices with their demographics was also made. The results showed that 72% of health practitioners were not knowledgeable on medication error reporting. The pharmacists have the highest proportion (38%) of knowledgeable respondents. Majority of the health practitioners (58%) were classified to have unfavorable attitude towards medication error reporting. Only the pharmacists have higher proportion of respondents (52%) with favorable attitude. More than half of the respondents (52%) are practicing medication error reporting. Among other variables, the age and frequency of encounter with medication errors affected the respondents’ knowledge while the manner of reporting affected their practices. Based on the results, it can be concluded that an improvement in medication error reporting system is still needed. Strengthening education about reporting is one of the ways to do such. Reporting system that may encourage health practitioners to report without having any doubt must also be established properly in hospitals to be able to improve patient care