The study was carried out to evaluate Proconvulsive effect of ofloxacin on electro convulsion & chemo convulsion and also to see its effect on locomotor activity in mice. The animals were given either saline (0.2 ml) or ofloxacin (25 mg/kg) intraperitoneally (i.p.) and the effect on spontaneous locomotor activity and maximal electroshock induced seizures (MES) was recorded. The mice were also given single & multiple doses of saline (0.2 ml i.p) or ofloxacin (25 mg/kg i.p.) and then they were subjected to sub convulsive doses of pentylenetetrazole (40 mg/kg i.p.) or picrotoxin (1 mg/kg i.p.) or strychnine (0.5 mg/kg i.p.). In results-the ofloxacin did not change the spontaneous locomotor activity or duration of tonic extension of hind limb of MES induced seizure significantly as compared to control group. Mortality was more in ofloxacin group after MES than the control group (30% vs 20%). No convulsions or jerky movements were seen after giving convulsants during single as well as multiple dose studies. Also no deaths were seen during subsequent 24 hours. The results indicate that ofloxacin may not have proconvulsant effect although higher doses of ofloxacin or other fluoroquinolones may be having this kind of adverse effects.

Severe falciparum malaria is a common and fatal malarial illness. The recommended regimen for severe falciparum malaria includes either artesunate or quinine based treatment. 100 patients of severe falciparum malaria were divided into two groups and randomly assigned to either ARTESUNATE or QUININE based regimen. A detailed clinical and biochemical evaluation of both groups was compared. Most common clinical signs were pallor, icterus, hepatosplenomegaly, altered sensorium and decreased urine output. 30% of patients had GCS <11, 87% had serum lactate >5mmol/L, S. Bilirubin was raised in 50% but abnormal AST/ALT was found in all patients and equally distributed in both groups. Of the two regimens hypoglycemia during treatment was more common in QUININE group than ARTESUNATE group (30% vs 12%), there was also increased mortality in quinine group (13 vs 7) but was not statistically significant. However, mean hemoglobin rise, normalization of GCS, LFT, time to death and coma recovery time were no different in two groups. Among the quinine treated patients there was an increased incidence of hearing disturbances (24%), QT interval prolongation (6%), ARF (4%) and visual disturbance was present in one patient.

The prevalence of use of analgesics is high. The main stay of treatment of pains is the Non-steroidal Antiinflammatory Drugs (NSAIDs). The aim of this study was to evaluate the prevalence and pattern of use of NSAIDs. 254 questionnaires were administered randomly to respondents that consented after carefully explaining the objective of the study. There were more females (61%); 89.4% were aged 18-45 years; 61% had secondary education; 56.3% were artisans of various trades; 96.5% were Christians. Majority (76.8%) had annual incomes of Naira100, 000-500,000. All respondents had ever taken pain relievers; Ibuprofen was used most frequently (49.2%), followed by diclofenac potassium (46.5%) and acetaminophen (41.7%).Respondents sometimes used pain relievers to manage headache (79.5%), general body pains (72.4%);body weakness (64.6%), stomach pains (63%); 71.7% ever indulged in multi-drug therapies involving more than one pain killer. Half the respondents preferred their choice of pain killer based on effectiveness; 99.2% and 90.2% respectively followed the instructions of the chemist and health professionals. Respondents reported that high cost of pain killers (72.8%), out-of-stock syndrome for preferred brands (58.0%), noneeffectiveness (57.6%) and the distance to procure the medication (54.3%) sometimes stood as barriers to access to pain killers;61% spent N 501-2000 monthly on pain killers. Education and marital status were correlated with pattern of use; gender, age, marital and educational status were all correlated with use of combination pain killers. There is urgent need to educate the people in this community on the rational use of pain drugs.

Acute eosinophilic pneumonia (AEP) is a potentially life threatening adverse event associated with exposure to more than 300different medications including antibiotics such as daptomycin. Definitive diagnosis of this process presents a challenge given the overlap of clinical characteristics with alternative diagnoses and potential lack of awareness. We present a case of daptomycin-induced AEP and a review of the currently available literature regarding diagnosis and treatment of AEP