Among all the dosage forms available solid dosageforms widely accepted among the patients of different age groups. Drugs with poor aqueous solubility and those which undergo degradation in aqueous medium can preferentially formulated as solid dosageforms which include tablets,capsules, powders etc. These provide improved patient compliance and enhanced pharmacokinetics and improved bioavalilabity compared to other dosageforms. The test which are performed during the manufacturing of product which include thickness, hardness, friability, dissolution time, disintegration time. Inprocess quality control test is necessary to insure the safety of finished pharmaceutical product. In the present study we analysted the quality control tests for tablets and capsules.

Diabetes mellitus is a multifactorial disease which is characterized by hyperglycemia, lipoprotein abnormalities, raised basal metabolic rate, defect in reactive oxygen species scavenging enzymes and altered intermediary metabolism of major food substances. Diabetes is a major degenerative disease in the world today, affecting at least 150 million people and having complications which include hypertension, atherosclerosis and microcirculatory disorders. The crude methanolic extract of Acacia nilotica bark with different soluble partitionates were subjected to investigate for the evaluation of analgesic, hypoglycemic, CNS depressant and antidiarrheal activity on mice and thrombolytic, anthelmintic, antimicrobial, antioxidant along with cytotoxicity different in vivo experiment. Hypoglycemic activity of the plant Acacia nilotica was evaluated and the result depicted that the Methanolic crude extract, Dichloromethane fraction at a dose of 400mg/kg body weight showed significant hypoglycemic activity compared to the standard.

Non-alcoholic fatty liver disease (NAFLD) refers to the accumulation of hepatic steatosis not due to excess alcohol consumption. It is the most common liver condition in the world. The prevalence of NAFLD is up to 30% in developed countries and nearly 10% in developing nations. The aim of this study was to assess serum ferritin level among Sudanese with non-alcoholic fatty liver disease. This was a case control study conducted in Advance diagnostic center, Bahary hospital, Khartoum state, Sudan in April 2017. Participants were divided into two groups; patients with non-alcoholic fatty liver disease (N/40), and 40 normal healthy individuals as control group. Serum Ferritin will was measured by using automated enzyme immunoassay system (TOSOH). The study results revealed that there is a significant difference in serum ferritin between cases and control group (P = 0.03). The study also showed moderate positive correlation between ferritin and age (R = 0.412), (P = 0.00). Patients with NAFLD have higher serum ferritin level than those without fatty liver changes. Serum ferritin levels rise as grade of liver steatosis increases.

The content of the work is to determine the role of methanolic root extract of Clerodendrum serratum (CS) in amnesia induced mice by using β-amyloid peptide and compared with normal mice. The CS having anti-cancer, antihelmenthic activity. But, the activity of root extract of CS as neuroprotective was not reported. Hence, the root extract of CS was tested for neuroprotective activity in neurodegenerative mice. The root extract were subjected to behavioral tests such as conditioned avoidance test, rectangular maze test, water maze test. Further, effect of extract on acetylcholinestarase, peroxidase, MDA levels and antioxidant activity is tested. From the results, it was observed that the root extract of CS exhibited statistically significant anti-amnesic and anti oxidant activity, when compared to normal mice. Therefore, the results conclusively demonstrate that, the chemical constituents of root extract responsible for neuroprotective activity, which might be due to oxidative stress.

Medicinal plants and their products play a vital role in human health for the treatment of inflammatory conditions. The validity of claims of many of these preparations has been substantiated by modern scientific methods and techniques. This present study was aimed to evaluate the anti-inflammatory activity of Impatiens balsamina roots and stems. Ethanol and water extracts of I. balsamina roots and stems were separately prepared by cold maceration method. The anti-inflammatory activity was evaluated using carrageenan induced paw edema method in wistar albino rats. Extracts at a dose of 50mg/kg was orally administered to the experimental rats 30mint prior to administration of carrageenan (0.1ml of 0.1%w/v). The paw volume was measured using digital plethysmometer at specific intervals. All three extracts exhibited significant anti-inflammatory activity. Ethanol extract of I. balsamina roots and ethanol extract of I. balsamina stems showed high significant (p<0.001) anti-inflammatory activity followed by water extract of I. balsamina stems at the 2nd hour. Ethanol extract of I. balsamina roots exhibited high spectrum of anti-inflammatory activity than ethanol extract of I. balsamina stems. The anti-inflammatory action of I. balsamina may be due to the presence of alkaloids, glycosides, terpenoids, flavonoids, phenolic compounds and tannins in the extracts. The findings suggest that the extract of I. balsamina roots and stems explore anti-inflammatory activity and leads the further development of novel natural anti-inflammatory agent.