In process quality control tests of solid dosage forms: a comprehensive review
Teja Dasari, Sai Lakshmi Jyothirmai Kala, Rama Rao Nadendla
Sch Acad J Pharm | 334-345
DOI : 10.21276/sajp
Abstract
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Among all the dosage forms available solid dosageforms widely accepted among the patients of different age
groups. Drugs with poor aqueous solubility and those which undergo degradation in aqueous medium can preferentially
formulated as solid dosageforms which include tablets,capsules, powders etc. These provide improved patient
compliance and enhanced pharmacokinetics and improved bioavalilabity compared to other dosageforms. The test which
are performed during the manufacturing of product which include thickness, hardness, friability, dissolution time,
disintegration time. Inprocess quality control test is necessary to insure the safety of finished pharmaceutical product. In
the present study we analysted the quality control tests for tablets and capsules.
Original Research Article
Aug. 22, 2017
Evaluation of Hypoglycemic Effect of Crude Extracts and Different Fractions of Stem Bark of Acacia nilotica
Mamun-Or-Rashid, Muhammad Ashiqul Islam, Taniya Idris, Shah Amran
Sch Acad J Pharm | 346-358
DOI : 10.21276/sajp
Abstract
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Diabetes mellitus is a multifactorial disease which is characterized by hyperglycemia, lipoprotein
abnormalities, raised basal metabolic rate, defect in reactive oxygen species scavenging enzymes and altered
intermediary metabolism of major food substances. Diabetes is a major degenerative disease in the world today, affecting
at least 150 million people and having complications which include hypertension, atherosclerosis and microcirculatory
disorders. The crude methanolic extract of Acacia nilotica bark with different soluble partitionates were subjected to
investigate for the evaluation of analgesic, hypoglycemic, CNS depressant and antidiarrheal activity on mice and
thrombolytic, anthelmintic, antimicrobial, antioxidant along with cytotoxicity different in vivo experiment.
Hypoglycemic activity of the plant Acacia nilotica was evaluated and the result depicted that the Methanolic crude
extract, Dichloromethane fraction at a dose of 400mg/kg body weight showed significant hypoglycemic activity
compared to the standard.
Original Research Article
Aug. 26, 2017
Association between Serum Ferritin level and Non Alcoholic Fatty Liver Diseases in Khartoum Sudan
Waleed Mohamed Alameen Al-Zibair, Mariam Abbas Ibrahim, Abdelgaidr Eltom
Sch Acad J Pharm | 359-362
DOI : 10.21276/sajp
Abstract
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Non-alcoholic fatty liver disease (NAFLD) refers to the accumulation of hepatic steatosis not due to excess
alcohol consumption. It is the most common liver condition in the world. The prevalence of NAFLD is up to 30% in
developed countries and nearly 10% in developing nations. The aim of this study was to assess serum ferritin level
among Sudanese with non-alcoholic fatty liver disease. This was a case control study conducted in Advance diagnostic
center, Bahary hospital, Khartoum state, Sudan in April 2017. Participants were divided into two groups; patients with
non-alcoholic fatty liver disease (N/40), and 40 normal healthy individuals as control group. Serum Ferritin will was
measured by using automated enzyme immunoassay system (TOSOH). The study results revealed that there is a
significant difference in serum ferritin between cases and control group (P = 0.03). The study also showed moderate
positive correlation between ferritin and age (R = 0.412), (P = 0.00). Patients with NAFLD have higher serum ferritin
level than those without fatty liver changes. Serum ferritin levels rise as grade of liver steatosis increases.
Original Research Article
Aug. 29, 2017
Neuroprotective Effect of Clerodendrum serratum in Amyloid β(25-35) Induced Amnesia Mice
Thirupathi G, Babu Rao B, Narsimha Reddy Y
Sch Acad J Pharm | 363-367
DOI : 10.21276/sajp
Abstract
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The content of the work is to determine the role of methanolic root extract of Clerodendrum serratum (CS) in
amnesia induced mice by using β-amyloid peptide and compared with normal mice. The CS having anti-cancer, antihelmenthic activity. But, the activity of root extract of CS as neuroprotective was not reported. Hence, the root extract of
CS was tested for neuroprotective activity in neurodegenerative mice. The root extract were subjected to behavioral tests
such as conditioned avoidance test, rectangular maze test, water maze test. Further, effect of extract on
acetylcholinestarase, peroxidase, MDA levels and antioxidant activity is tested. From the results, it was observed that the
root extract of CS exhibited statistically significant anti-amnesic and anti oxidant activity, when compared to normal
mice. Therefore, the results conclusively demonstrate that, the chemical constituents of root extract responsible for
neuroprotective activity, which might be due to oxidative stress.
Original Research Article
Aug. 29, 2017
Anti-inflammatory Activity of Impatiens balsamina Roots and Stem
N. Neevashnhi, K. Anandarajagopal, J. Anbu Jeba Sunilson
Sch Acad J Pharm | 368-371
DOI : 10.21276/sajp
Abstract
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Medicinal plants and their products play a vital role in human health for the treatment of inflammatory
conditions. The validity of claims of many of these preparations has been substantiated by modern scientific methods and
techniques. This present study was aimed to evaluate the anti-inflammatory activity of Impatiens balsamina roots and
stems. Ethanol and water extracts of I. balsamina roots and stems were separately prepared by cold maceration method.
The anti-inflammatory activity was evaluated using carrageenan induced paw edema method in wistar albino rats.
Extracts at a dose of 50mg/kg was orally administered to the experimental rats 30mint prior to administration of
carrageenan (0.1ml of 0.1%w/v). The paw volume was measured using digital plethysmometer at specific intervals. All
three extracts exhibited significant anti-inflammatory activity. Ethanol extract of I. balsamina roots and ethanol extract of
I. balsamina stems showed high significant (p<0.001) anti-inflammatory activity followed by water extract of I.
balsamina stems at the 2nd hour. Ethanol extract of I. balsamina roots exhibited high spectrum of anti-inflammatory
activity than ethanol extract of I. balsamina stems. The anti-inflammatory action of I. balsamina may be due to the
presence of alkaloids, glycosides, terpenoids, flavonoids, phenolic compounds and tannins in the extracts. The findings
suggest that the extract of I. balsamina roots and stems explore anti-inflammatory activity and leads the further
development of novel natural anti-inflammatory agent.