Original Research Article
March 30, 2018
Saxagliptin versus Glimepiride Combination with Metformin in Type 2 Diabeted Mellitus
Mu’tazbellah F. Alzubi, Amal S. Aljariri, Deema A. Gawgneh, Ola A. Aldmour, Niveen A. Alabbadi, Hayat Y. Hilan
Sch Acad J Pharm | 115-119
DOI : 10.21276/sajp.2018.7.3.2
Abstract
PDF
Full Texts
e-Pub
Various groups of oral hypoglycemic agents (OHAs) are recently available, but
there is a need for agents with different mechanisms of action that achieve better efficacy
and can be used either as monotherapy or in combination with treatment regimens.
Dipeptidyl peptidase-4 inhibitors improve glycemic control in patients with type 2
diabetes mellitus (T2DM) when used as monotherapy or in combination with other
OHAs. The main aim of the present study is to compare the effects of Saxagliptin versus
Glimepiride on efficacy of treatment in patients with T2DM in combination with
metformin. A retrospective observational study will be performed on patients each in
(Saxagliptin+Metformin) and (Glimepiride+Metformin) group, who are receiving
treatment for at least 12 weeks. Glycated hemoglobin (HBA1c) will be the chief
parameter of efficacy. At 12 weeks both groups (Saxagliptin and Glimepiride) produced
significant
Nanostructures in Drug Delivery System
Sham V. Ingole, Sumedh N. Moharil, Prajakta K. Bansod, Sohal A. Jadhav
Sch Acad J Pharm | 105-114
DOI : 10.21276/sajp.2018.7.3.1
Abstract
PDF
Full Texts
e-Pub
The technology used for to design, characterization and synthesis of smallest
particulate system term as nano called nanotechnology and having diamension has
monometer. Nanotechnology should not be viewed as a single technique that only affects
specific areas. Advances in nanotechnology were utilized in medicine for therapeutic drug
delivery and treatment for variety of diseases and disorders. The various type of
Nanostructured Drug Delivery System are available like liposomes, Dendrimers, GNP,
SLN, PN, MN, Metalic nanoparticles, CM, SM, ME and NE, NT, NC, NF, and QD etc.
The reason review gives all details information about all the system which is important in
Nanostructered Drug Delivery System. So it is advantege and gives reduce the doses
required that type of advantage.
Original Research Article
March 30, 2018
Factors Affecting Adherence to Medications among Hypertension Patients
Amal S. Aljariri, Najwa A. Alomari, Mu’tazbellah F. Alzubi, Ola A. Aldmour, Ghadeer M. Aljamain, Alaa’ A. Alryalat
Sch Acad J Pharm | 120-129
DOI : 10.21276/sajp.2018.7.3.3
Abstract
PDF
Full Texts
e-Pub
Non-adherence to management of chronic illness is a global concern of
prominent degree. Information on adherence to antihypertensive drugs (AHDs) and blood
pressure control among hypertension patients in Jordan is scanty. This study will be
conducted to assess the rate of adherence and to explore factors associated with nonadherence to AHDs among ambulatory patients with hypertension in a King Hussein
Medical Centre (KHMC) at the Royal Medical Services (RMS) in Jordan/Amman. A
descriptive cross-sectional design will be used to collect quantitative data. Structured
questionnaire containing the Morisky Medication Adherence Scale (MMAS) will be
utilized to collect information necessary to assess medication adherence. Demographic
and clinical data will be taken from the patients’ medical records. The self-reported
adherence rate to AHDs was 25.9 %. The adherence rate was approximately similar in
both genders, and the most common reasons for non-adherence were multiple drug
therapy and forgetfulness. Patients with governmental job,
Original Research Article
March 30, 2018
Proper Timing of Prophylactic Antimicrobial Administration in Orthopedic Surgeries
Ala’a R. Alabbadi, Tariq M. Alsabra, Shereen E. Hijazeen, Ahmad A. Hiasat, Iqbal Almomani, Tamer Alzoubi, Esra’a Alawneh, Moath F Alzoubi
Sch Acad J Pharm | 130-133
DOI : 10.21276/sajp.2018.7.3.4
Abstract
PDF
Full Texts
e-Pub
Correct timing of administration is vital for ensuring the efficacy of
prophylactic antimicrobials in preventing surgical site infection (SSI). Insufficient
commitment to perioperative antimicrobial prophylaxis guidelines has been observed, but
there is a rareness of information on this subject from Jordan. The main aim of this study
is to find the appropriateness of administration of the first dose of prophylactic
antimicrobials in orthopedic surgeries. An observational study will be performed in the
Royal Rehabilitation Centre (RRC) in the Royal Medical Services (RMS); administration
of antimicrobials in operations done over a 2-month period was examined. The major
outcome measure will be timing of antimicrobial administration in relation to skin
incision and tourniquet application. Ideal timing will be defined as prophylactic
antimicrobial administration 15-60 min before skin incision or tourniquet application.
Original Research Article
March 30, 2018
Effect of Telmisartan on Learning and Memory in Albino Rats
Uma Shanker Prasad Keshri, Sumit Kumar Mahato, ManjuGari, Akhilesh Kumar, Rajiv Kumar
Sch Acad J Pharm | 134-138
DOI : 10.21276/sajp.2018.7.3.5
Abstract
PDF
Full Texts
e-Pub
Dementia is a syndrome of gradual onset and continuous decline of higher
cognitive function. By 2050, more than 115 million people will have dementia. The
prevalence of dementia rapidly increases from about 2-3% among those aged 70–75 years
to 20–25% among those aged 85 years or more. Etiology of dementia is Alzheimer’s
disease (AD), vascular dementia, and other neurodegenerative disease. Discovery of
complete Renin angiotensin system (RAS) in the brain, and Potential function of Ang II
in the etiology of certain neurodegenerative diseases, including Alzheimer’s and
Parkinson’s disease, seizures, and the development of metabolic syndrome and diabetes.
Telmisartanpossess partial peroxisome proliferators’ activator receptor gamma (PPAR)
agonistic activity. PPAR-γ agonists have been reported to effectively attenuate oxidative
stress, inflammation and apoptosis in the central nervous system (CNS). Wister albino
rats weighing between 150-250 grams were taken for the present study. Rats were divided
in five different groups,
Original Research Article
March 30, 2018
Antidiarrheal and Antimicrobial Activities of Ethno Medicinal Plant: Mikania scandens (L) Willd
Jana Soma, Yalagatti S Manjunath, Gupta V Rama Mohan
Sch Acad J Pharm | 139-147
DOI : 10.21276/sajp.2018.7.3.6
Abstract
PDF
Full Texts
e-Pub
The aim of the present study was carried out to investigate the antidiarrheal
and antimicrobial potential of both ethanol and aqueous extracts of aerial parts of Mikania
scandens .In vivo Antidiarrheal activity of M.scandens ethanol and aqueous aerial extracts
at a dose of 100 mg/kg and 200 mg/kg BW were studied using experimentally induced
castor oil diarrheal in Wister rats of both sexes and compared to standard drug loperamide
(3mg/kg p.o). During this study different parameters like time of onset of diarrhoea, total
nos. of faecal output (frequency of defecation) and weight of wet faeces, nos. of wet
faeces were assessed. In vitro Antimicrobial activity (zone of inhibition, minimum
inhibitory concentration, minimum bactericidal concentration, minimum fungal
concentration) were performed by using four bacterial strains.( gram positive, & gram
negative) and two fungal strains. Data were analysed using one way ANOVA. (Analysis
of Variance).The results of antidiarrheal studies showed that over four hours, both the
extracts significantly protected
Liquisolid Compact Technique for Improvement of the Dissolution Rate: A Review
Athira T Vijayan, K Krishnakumar, B Dineshkumar, Smitha K Nair
Sch Acad J Pharm | 148-154
DOI : 10.21276/sajp.2018.7.3.7
Abstract
PDF
Full Texts
e-Pub
The liquisoid compact technique is a promising technique to enhancing the
dissolution of poorly water soluble drugs. About 40% of newly discovered drugs are
poorly water soluble or water insoluble categories. Simple processing low cost and great
potentials in industrial production are the main advanges of this technique. By using this
technique, the liquid medications such as solutions or suspension of water insoluble drug
can be easily converted in to powder with acceptable flow properties using suitable
powder excipient. This review article is focused the formulation of liquisolid systems,
classification of liquisolid systems, evaluation and its applications in the field of
pharmaceutical sciences.
Original Research Article
March 30, 2018
Development and Validation of Dimenhydrinate Analysis Method in Tablet with Absorbance Method and Method of Area under Curve with Ultraviolet Spectrophotometry
Harrizul Rivai, Nindry Selma Nofera, Zikra Azizah
Sch Acad J Pharm | 155-163
DOI : 10.21276/sajp.2018.7.3.8
Abstract
PDF
Full Texts
e-Pub
Methods of ultraviolet spectrophotometry have been developed and validated
for the analysis of dimenhydrinate in tablets with absorbance methods and methods of
areas under the curve. This method uses 0.1 M HCl as a solvent and wavelength of 276.20
nm. The area under the curve is measured at a wavelength of 245.60-304.60 nm. The
calibration curve was obtained in the concentration range of 10-30 μg / mL. Method of
absorbance shows linear regression equation y = 0,105 + 0,019x and value r = 0.99983;
wide-area-under-curve method shows linear regression equation y = 2.248 + 0.472x and r
= 0.9985. Dimenhydrinate content in trademark tablets with absorbance method was
105.09% and with the method of area under the curve was 104.56%. Dimenhydrinate
content in generic tablet with absorbance method is 93.86% and with method of area
under the curve is 94.34%. Dimenhydrinate levels in both samples were eligible
according to Pharmacopoeia edition V of 90-110%. The recovery and the relative
standard deviation (RSD) obtained from both samples by absorbance method and the
area-under-curve method met the requirements of the validation parameters, i.e. 80-120%
and 0-2%, respectively. Statistical analysis showed that there was no significant
difference between the two methods
Original Research Article
March 30, 2018
Evaluation of Anti Diabetic Activity (In-vitro) of Psidium guajava Unripe Fruits Aqueous Extract
A. Narayana Rao, Donthu Susmitha, Gurajala Lalitha, Mandhalapu Sesha Pavani, Shaik Yakoob, Velpula Sai Tejaswini, Tanuku Satyanarayana
Sch Acad J Pharm | 164-170
DOI : 10.21276/sajp.2018.7.3.9
Abstract
PDF
Full Texts
e-Pub
Diabetes Mellitus is a major endocrine disorder caused by the failure of the
body function properly carbohydrate metabolism as well as changes in lipid and protein
metabolism, thus contributing to hyperglycemia (increased blood sugar levels above
normal), glycosuria (the presence of sugar in the urine), polyuria (the need to urinate
frequently), polydipsia (always thirsty) and polyphagia (increase appetite). Numerous
herbal plants and their formulations are therefore used widely for the various forms of
diseases. One well-known herb of this kind is Psidium guajava Linn (Family: Myrtaceae)
is a semi deciduous tropical tree commonly known as guava or ‘Amrood’ in north India
and is widely grown throughout India. The present study was undertaken to evaluate the
Anti diabetic activity (In-vitro) of Psidium guajava unripe fruit aqueous extact. The
Evaluation of anti-diabetic activity of extract by In-vitro method by glucose uptake by
yeast cells the rate of uptake of glucose into the yeast cells was linear in all the 3 glucose
concentrations. The extract of Psidium guajava exhibited significantly activity than the
control. However,
