Original Research Article
Oct. 15, 2020
Evaluation of Factors Associated with Enoxaparin Therapy in South Indian Patients
Krishna Kumar Dhakchinamoorthi, John Thomas Palathingal, Muppalla Geethanjali, Paichava Anudeep, Kiruthiga Kannan
Sch Acad J Pharm | 283-289
DOI : 10.36347/sajp.2020.v09i10.001
Objective: The objective of the study was to find various factors involved in enoxaparin therapy in South Indian patients. Materials & Methods: A retrospective data analysis was carried out over six months and 203 patients received enoxaparin therapy were included for the study. All patient’s data (patient demographic, past medical and medication history, and complaints on admission, laboratory parameters and medication treatment) were collected from the patient’s medical records. Results: The mean age group of the study population was found to be 55.1±13.3 (95% CI 53.23 – 57.03) years. The mean enoxaparin dose to reach mean aPTT was found to be 2.1±1.2 ml (95% CI 1.89- 2.25). The mean duration of heparin therapy was 3.6 days and the time to reach aPTT was found to be 2.8 days. The average first value of aPTT was found to be 31.9±5.9 (95% 31.11 - 32.68) sec. The mean enoxaparin dose significantly differed between patients with different BMI groups (p<0.001). Stepwise univariate and multivariate linear regression analysis revealed that weight (kg) was the major determinant (20.6%) followed by time to reach target aPTT (12.2%) systolic blood pressure (2.2 %), Serum creatinine (2.0%) and Blood Urea Nitrogen (1.7%) were the other determinants of enoxaparin dose requirements (linear regression model p<0.001). Conclusion: The major determinants of enoxaparin (LMWH) dose requirements were patients' body weight and time to reach the required aPTT levels, considering these factors before starting enoxaparin will improve anticoagulation outcomes in patients undergoing various surgeries.