DOI: 10.36347/sjmcr.2019.v07i04.010

Pages: 299-302

The tonsil is one of the most frequent sites of involvement of non-Hodgkin lymphoma in the head and neck, Chemotherapy combined with radiation therapy (RT) is considered the standard treatment for limited-stage diffuse large B-cell lymphoma. However, in longterm follow-up studies involving the use of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP), the role of RT requires clarification. Our purpose is to present a case of unilateral tonsillar lymphoma successfully treated with R-CHOP chemotherapy alone. A 77 year old woman presented with a mass in the right palatine tonsil. No peripheral lymphadenopathy was detected. High fludeoxyglucose uptake was noted in the right palatine tonsil (SUVmax: 13.8) on positron emission tomography. The histological examination of tonsillar biopsy confirmed the diagnosis of non-Hodgkin lymphoma Germinal center B-cell-like (GCB) diffuse Large B-cell Lymphoma (DLBCL). She was staged as IA according to the Ann Arbor staging system with low risk international prognostic index (IPI). Treatment with 6 cycles of R-CHOP chemotherapy led to obtain a metabolic complete remission after 3 cycles. During follow-up, she remains disease-free exceeding one year.