DOI: 10.36347/SAJP.2019.v08i11.008

Pages: 514-519

The Herbal Transdermal Patches was designed for sustained drug release and improve bioavailability of drug and patient compliance achieve via. Transdermal Drug Delivery System (TDDS) by using, Gymnema sylvestre extract and formulation of gymnemic acid. The powdered of dried leaves of Gymnema Sylvestre is treated for methanolic extraction (90% methanol) continuous hot extraction method using Soxhlet apparatus for upto 6-8 hours, then isolated Gymnemic Acid was Analysis done with help of UV at lamda max 240nm whether absorption obtained and HPLC methods in which Reverse phase chromatography of C-18 column at room temperature and isocratic elution of solvent system with Acetonitrile: Buffer using (23:77v/v), at flow rate of 2.0 mL/min. Then preparation of Transdermal herbal patch of Gymnemic Acid their evaluation parameters like Thickness, Folding Endurance, Content Uniformity, which would be ability to reduce or maintains blood sugar level potentially developed as an Antidiabetic activity.