DOI: 10.36347/sajb.2018.v06i04.001

Pages: 299-302

Influenza an infection has been found to be associated with disseminated intravascular coagulation (DIC) and pulmonary micro embolism. This study assesses marker of thrombus formation (FDP, D-dimer levels) in H1N1 patients and their association with morbidity (hypoxia) and mortality. The preliminary data of an ongoing, analytical, case-control study among H1N1 infected are presented. Twenty H1N1 infected patient having radiographic evidence of pneumonia, having age >18 years and less than 60 years were included in this study, after taking informed consent (the case). Twenty age and sex matched were also included in this study that had bilateral pneumonia, but were H1N1 negative (the control). The patients who had heart disease, cerebro-vascular diseases, haemorrhagic disorder, coagulation disorder, diabetes, hypertension, received injection recently, hepatic disorder, malignancy, recent surgery or infections other than H1N1 were excluded. Pregnant females were also excluded from this study. The nasopharyngeal-swab specimens were collected from each study participants at the time of hospitalization and analysed by of a real-time reverse-transcriptase–polymerase- chain-reaction (RT-PCR) assay. The venous blood samples were taken for FDP and D-dimer at same time. Among the 20 cases, 13/20 were FDP positive, and 5/20 controls were FDP positive (P<0.05). Hypoxia was higher in cases (17/20) as compared to controls (7/20) (P<0.05). FDP positivity was associated with significantly higher frequency of hypoxia (15/20) and high mortality (10/20) (P<0.05 for each). D-dimer positivity was associated with significantly higher frequency of hypoxia (15/20) and high mortality (10/20) (P<0.05 for each). D-dimer/FDP positivity was associated with significantly higher frequency of hypoxia and high mortality in H1N1 infected patients.