DOI: 10.36347/sjmcr.2021.v09i04.027

Pages: 404-408

Digoxin is extracted from digitalis and is commonly used in patients with atrial fibrillation and in patients with heart failure. Advanced digitalis intoxication can have a fatal outcome, particularly in patients with underlying cardiac dysfunction (1). Drug-induced thrombocytopenia (DITP), although frequent, remains exceptional in the event of overdose with digoxin. An overdose of Digoxin is usually iatrogenic and mainly leads to cardiac effects but can also cause severe thrombocytopenia. However, this latter complication related to digoxin is “exceptional”. The lifelong prognosis does not depend on a hemostasis disorder but rather on a secondary cardiac arrhythmia. We hereby report the observation of a 62- year-old patient followed for a dilated cardiomyopathy with a severe left ventricular dysfunction, and also an atrial fibrillation treated with acenocoumarol and digoxin. She has been admitted to the emergency room due to a partial loss of consciousness associated with dizziness and vomiting. Hence, we will discuss here explanatory approaches to the unresolved mechanism of this undesirable effect, scarcely described in the literature.