In the inflammation process, the enzyme cyclooxygenase-2 expressed and its function is prostaglandins synthesis of from arachidonic acid so that to inhibit inflammation proses, COX-2 must be inhibited. In current research a twenty-six flavonoids compounds included flavonols (n= 10), flavones (n= 7) and anthocyanins (n= 9) were studied to predict their affinity to attach to the active site of both COX-1 and COX-2 enzymes and to predict the selectivity of each compound to COX-2, this done using docking method. Docking simulation for each compound done using 1-click docking tool. Some of the studied compound (n= 13 ) had strong predicted affinity to COX-2 combined with strong affinity to COX-1, so that they are non-selective inhibitors, additionally, an exception was found for Rosinidin and Pulchellidin which tends to bind to COX-2 with stronger affinity than COX-1, as (-8.1, -7.6,) and (-6.5, -5.2, -2.8) respectively.

Interaction study is the most important step in reformulation study for the preparation of all dosage forms. The interaction can affect physical, chemical, therapeutic and biological properties and stability of drug and create a new surprise problem, the successful formulation of stable and effective solid dosage form depends on the careful and suitable choice of excipient. Also the selection of excipient is vital in the design of a quality drug product. The quality of medicine depends not only on the active principals and productions process, but also on the performance of the excipients .The present work shows the interaction study of Lornoxicam and polymers for Nano products. In IR the interaction of infrared radiation with matter. It covers range of techniques, mostly based on absorption spectroscopy. DSC is a thermo-analytical technique in which the difference in the amount of heat required to increase the temperature of sample and reference is measured as a function of temperature.

Cardiovascular diseases are major causes for morbidity and mortality worldwide, among this myocardial infarction is one of them. Myocardial infarction can be diagnosed by physical examination of the patient, electrocardiogram, angiography and biomarkers. Since 40 years, cardiac biomarkers were extensively using for diagnosis of cardiac abnormalities. AST was the first biomarker used in year 1954. Myoglobin, Creatinine kinase, Troponin, lactate dehydrogenase were established biomarkers and Myeloperoxidase, Copeptin, Growth differentiation factor (GDR-15), Heart type fatty acid-binding protein (H-FABP),B-type natri-uretic peptide(BNP) and N-terminal fragement of pro-BNP, High sensitive C-reactive protein (hs-CRO), Placental growth factor (PIGF), Whole blood choline(WBCHO) and plasma choline, Pentraxin 3(PTX-3), Pregnancy associated plasma protein A(PAPPA), Soluble cluster of differentiation 40 ligand, Ischemia modified albumin(IMA) were emerging biomarkers. In this review we mainly focused in the diagnostic and prognostic information of various biomarkers used for diagnosis of myocardial infarction.

Indians have a high prevalence of Metabolic Syndrome (MetS) which carries multiple risk factors. Since a scarce information is available about the magnitude of Metabolic Syndrome amongst the geriatric population in India. Present case was taken up to ascertain the risk factors and management MetS. In this cases hypertension, T2DM, insulin resistance, obesity, dyslipidemia, IHD, low sedentary life style activities, and nonadherence to the medications are the major contributing risk factors for MetS and it was managed by the effective therapeutic regimens, supportive therapy and counselled the patient about disease condition, medications usage, and life style modifications to overcome or control the MetS.

The aim of the present study was to formulate and evaluate Pravastatin Sodium transdermal patch. Pravastatin is a lipid lowering agent, because of its short biological half life (t1/2, 1-3 hours) only 18% of its dose reaches to the systemic circulation of the blood on oral administration. Hence it is a suitable drug to formulate into transdermal form. Transdermal patchs of Pravastatin Sodium was prepared by using different polymers like HPMC 3000, HPMC K15M,HPMC E5 by solvent casting method. FTIR study reports have shown that there was no interaction between drug and excipients. The prepared patches were evaluated for Folding Endurance, Uniformity of weight, Drug content, Moisture content, In-vitro diffusion study, a series of 12 formulations were prepared by using different polymers composition in different concentrations among them F11 formulation prepared by using HPMC K15M was showed satisfactory results with 88.6% of drug release in diffusion studies was found to be suitable for formulating as transdermal patch in order to increase the bioavailability and to decrease the dosing frequency of Pravastatin Sodium.