Background: Metabolic syndrome is a multiplex risk factor that arises from hyperglycemia /insulin resistance accompanied with abnormal fat function &central obesity& possibility to develop diabetes mellitus type-2, atherosclerosis & various diseases. Aim of study: To determine the effect of ropinirole & metformin on glycemic Parameters, insulin sensitivity and lipid profile associated with metabolic syndrome. Patients and methods: The present study was performed in diabetic and endocrine center from May 2016 to march 2018. Ninety female patients with metabolic syndrome participate in this study .They were allocated to three groups (each group contain 30 patients) first group put on diet restriction physical exercise only. Second group received metformin 750mg extended release orally once daily at night with diet restriction & physical exercise. Third group received ropinirole 0.25 mg orally after meal in morning with diet restriction & physical exercise. The duration of the study extended to 12 weeks. Blood samples were taken from each patient at zero time to determine base line level & after 12 weeks of treatment. The measured parameters were WBC, BMI, FBS, FI, HOMA-IR, Hb A1c, TC, TG, HDL, LDL. Results: Showed highly significant lowering effect of both ropinirole & metformin on the levels of the all parameters except HDL with high significant elevation, at the mean time all the parameters of the control were significantly changed. Conclusion: Both drugs improve glycemic parameters, insulin sensitivity and lipid profile in metabolic syndrome but metformin is slightly more powerful on these parameters.

The contagious disease COVID-19 is a recently out-broken pandemic situation which threatens human kind all over the world. While considering the mortality and severity of this disease, the author attempted to identify the possible inhibition of RNA-dependent RNA polymerase (RdRP) or RNA replicase which catalyzes the replication of RNA from an RNA template by certain bioactive components. So certain herbs which are used as febrifuges in Siddha medicine were analyzed through molecular docking studies. The compounds Betulinicacid, Amaranthin, Betacyanin, Cadambine, 14 –deoxy Androgapholide, lupeol, Neoandrographolide, Tubulosin and Isovitexin have binding energy comparable to Remdesivir.

A simple, specific, accurate and precise UV Spectrophotometric method has been developed for the simultaneous estimation of Darunavir and Ritonavir in pharmaceutical dosage form. The absorption maxima of the Darunavir and Ritonavir were found to be 267 nm by using methanol and 240nm using methanol: water as solvent and isosbestic point found at 254nm. This method obeys beers law in the employed concentration range of 2-18μg/ml and 5-100μg/ml for Darunavir and Ritonavir respectively. Different analytical validation parameters such as linearity, precision, accuracy, limit of detection (LOD) and limit of quantification (LOQ) were determined according to ICH guidelines. The accuracy of the method was confirmed by recovery studies of tablet dosage form and was found to be 100% and 99% for Darunavir and Ritonavir respectively. The LOD of Darunavir and Ritonavir was found to be 0.043μg/ml and 0.024μg/ml respectively and LOQ of Darunavir and Ritonavir was found to be 0.132μg/ml and 00.078μg/ml respectively. The developed method was free from interferences due to excipients present in formulation and it can be used for routine quality control analysis.