A Comprehensive Review of the Analytical Development and Validation of Alprazolam in Bulk and Pharmaceutical Dosage Form
Gaurav M. Prajapati, Devang R. Ghuge
Sch Acad J Pharm | 88-93
DOI : 10.36347/sajp.2022.v11i05.004
Alprazolam is approved in 2003 by US FDA. Alprazolam is available as an extended-release tablet, a mouth dissolving tablet (a tablet that dissolves rapidly in the mouth), as well as a concentrated solution (liquid). For the treatment of severe anxiety and panic disorder, alprazolam is one of the most commonly prescribed benzodiazepines. IPUAC name of Alprazolam is 8-Chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a] [1, 4] benzodiazepine. The molecular formula and molecular Weight is C17H12ClFN4 and 326.75 g/mol. These articles may serve as an overview of Alprazolam with their drug profile, pharmacology, pharmacokinetics, and analytical HPLC procedures that are commonly employed in determining common provision issues. These reviews cover topics such as mobile phase, mobile phase ratio, column, retention time, flow rate, UV detector wavelength, run time, and more. Linearity, percent recovery, detection limit, and quantification limit are all validating parameters. The pharmaceutical analysis serves as an internal control for pure and pharmaceutical dosage forms, which is critical for quality assurance. The development of analytical methods has emerged as a crucial study activity.
Torsion of Fatty Appendage of Falciform Ligament: A Case Report
Tarik Anis, Ismail Labbi, Abdesslam Bouassria, Hicham El Bouhaddouti, Ouadii Mouaqit, El Bachir Benjelloun, Abdelmalek Ousadden, Khalid Ait Taleb
Sch Acad J Pharm | 85-87
DOI : 10.36347/sajp.2022.v11i05.003
Torsion of the fatty appendage of the falciform ligament is an extremely rare condition that leads to severe abdominal pain and raised inflammatory markers. It can be recognised on ultrasound or CT scan. The pathophysiology is the same as that involved in the more common torsion and/or infarction of the greater omentum or epiploic appendages. The condition is best managed conservatively with anti-inflammatory analgesia, and the early recognition of this type of torsion may prevent unnecessary operative intervention to look for a source of abdominal pain. We report a rare case of torsion of the fatty appendage of the falciform ligament associated with pancreatitis C in 71 years old women. The management consisted of surgical treatment after failure of medical treatment with a favorable outcome.
Diagnostic and Therapeutic Complexity of Gender Dysphoria: About A Clinical Case
M. Raissouni, S. Benhammou, H. Kisra
Sch Acad J Pharm | 81-84
DOI : 10.36347/sajp.2022.v11i05.002
Gender dysphoria is a medical term used in the American Psychiatric Association (APA) textbook to describe the distress of the transgender person in the face of a sense of inadequacy between their assigned sex and their gender identity. The work we present is based on a clinical case in which we have retained the diagnosis of gender dysphoria comorbid with other psychiatric disorders after several close consultation appointments, and through which we will address the socio-cultural aspect of this disorder within our society Adults with gender dysphoria can benefit from psychological, medical and surgical treatment in France. However, this dysphoria rarely appears in adulthood, often being present since childhood and adolescence and generating difficulties in family, social and school life, particularly at the time of puberty. It is necessary to take adequate care of patients with gender dysphoria, often generating psychological suffering responsible for numerous comorbidities.