The transdermal route is an important pathway for localized or systemic effects. The stratum corneum, the outer layer of the skin, is an essential skin permeation barrier for many drugs. To overcome this barrier, several techniques have been developed, including the use of the vehicle and nanocarriers to improve drug penetration. Recently, different types of nanocarriers have been designed to improve the dermal and transdermal delivery of medicines like ‘INVASOME’. We made clotrimazole loaded invasome gel which is used in fungal treatment. The procedure used in formulation of invasomal gel is mechanical dispersion method. This preparation is evaluate by many parameters they are appearance, spreadability, solubility, in vitro drug diffusion. And also discuss application of invasome.

Background: Asthma is a serious global health problem with an estimated 300 million affected individuals. Clinical manifestations of asthma can be controlled with appropriate treatment. When asthma is controlled, severe exacerbations should be rare. The goal of treatment in Asthma is to reduce inflammation and to achieve¸ total control. Treatment with anti-inflammatory drugs can, to a large extent, reverse some of these processes; however, the successful response to therapy often requires weeks to achieve and, in some situations, may be incomplete. Objectives of the study: This study was performed to evaluate the outcomes of Asthma treatment amongst asthmatic patients on follow-up at King Hussein Medical Centre (KHMC) at the Royal Medical Services (RMS) in Jordan/Amman. Methods: A retrospective, observational study was designed and performed on the basis of the asthma patient medical files. The patients’ medical profiles of were revised and the results were assessed according global initiative for asthma (GINA) guidelines. The collected data was analyzed by using statistical Package for the Social Sciences (SPSS) version 22. Results: A total of 210 asthmatic patient’s profiles were revised, and amongst the patient's majority (62.6%) were males and the average age of the participants was 35.1 years with standard deviation (SD) of 9.4. The most (53.3%) have been prescribed asthmatic drug combination was fluticasone propionate and salmeterol xinafoate (Seretide®) for long term asthmatic symptoms management. Amongst the asthmatic patients, 58 % had used antibacterial for their respiratory tract infections (RTIs) and urinary tract infections (UTIs). Conclusion: This study has shown that, despite the existence of an effective medication for asthma, disease control is insufficient and falls short of the accepted global guidelines.

The transdermal route is an important pathway for localized or systemic effects. The stratum corneum, the outer layer of the skin, is an essential skin permeation barrier for many drugs. To overcome this barrier, several techniques have been developed, including the use of the vehicle and nanocarriers to improve drug penetration. Recently, different types of nanocarriers have been designed to improve the dermal and transdermal delivery of medicines like ‘INVASOME’. We made clotrimazole loaded invasome gel which is used in fungal treatment. The procedure used in formulation of invasomal gel is mechanical dispersion method. This preparation is evaluate by many parameters they are appearance, spreadability, solubility, in vitro drug diffusion etc.