A Review: Why Aminopyrine Banned?
Jyoti Panchal, Gautam Kumar, Sakshi Dagar, Meenu Bhati, Deepika Thareja
Sch Acad J Pharm | 24-27
DOI : 10.36347/sajp.2021.v10i01.005
Aminopyrine is used as an antipyretic and analgesic drug. It belongs to the pyrazolone derivatives having a most toxic and most dangerous analgesic effect and it is a non-narcotic drug. It had been widely used in the clinical treatment of rheumatism because of its good efficacy. It was inexpensive drug and due to this reason, it was widely used in many countries. It causes agranulocytosis, aplastic anemia and blood dyscrasias in many patients. In this review, we are providing an overview of fatal side effects of aminopyrine drug such as neutropenia, acute renal failure, bone marrow depression and damage to stomach which are reported and make it banned in many countries. Because of its serious adverse effects, it has been withdrawn from most of the countries like France, Thailand and India. Aminopyrine is rarely used in the Europe like countries at present. In 1986, it was forbidden in Japan. The Committee on the Safety of Drugs of the Japanese Pharmaceutical Affairs Bureau has ordered for its withdrawal. Before that it was extensively used as analgesics, until its side effects were not reported. Even though it is in use at present time in some developing countries.
Original Research Article
Jan. 27, 2021
Evaluation of Bacteriological Quality of Packed Ice Creams Sold In Retail Stores in Tripoli City, Libya
Mohamed R. Alsagher, Izdehar M. Alahdab, Sahar N. Alkhwildi, Najat Elmaghrhi, Ayda Ghalboon and Raja M. Moman
Sch Acad J Pharm | 19-23
DOI : 10.36347/sajp.2021.v10i01.004
Ice cream is considered as one of the most favorable media for growing of bacterial species and as potential source of food poisoning. The main objective of the present study was to determine the bacterial loads of ice cream. A total of thirty samples of fourteen packed ice cream brands were collected from different retail stores in Tripoli city of Libya. Thereafter, their bacteriological quality were assessed and studied comparatively. Total Bacterial viable count (TBVC), total coliform count (TCC) were determined in plate count agar (PCA). Mannitol salt agar (MSA) and Eosin methylene blue (EMB) agar, Salmonella-Shigella agar and Listeria agar were used for Staphylococcus aureus, E. coli, Salmonella spp. and Listeria spp. count respectively. The results revealed that all samples had TBVC of cfu/g ranging from 1x104 to 8x104, in which 7 (23.3%) of the ice cream samples fell within the acceptable limit and met the standard plate count according to the Libyan Standard for Ice Cream (LSIC, 1997). By contrast, 7 samples (23.3%) showed zero TBVC. Moreover, 16 sample (53.3%) showed contamination with bacteria in a numbers too numerous to be counted (TNTC). However, on the basis of total coliform count, 20 samples (66.7%) showed high level of contamination. In conclusion, the majority of ice creams have been contaminated with pathogens in particularly Escherichia coli. Hence, it is recommend that a greater attention is needed to apply strict microbiological quality control to ensure the safety of final products of ice creams by improving the quality of production technology and sanitation strategies.
Original Research Article
Jan. 15, 2021
Evaluation of Some Biochemical Parameters of Envenomed Oryctolagus cuniculus
Obou Constantin Okou, Jacques Auguste Alfred Bognan Ackah, Abba Pacôme Obouayeba, Djané Hamed, Allico Joseph Djaman
Sch Acad J Pharm | 13-18
DOI : 10.36347/sajp.2021.v10i01.003
The general objective of this study was to evaluate the action of Naja nigricollis venom on certain biochemical parameters of rabbits. To carry out this study, three batches of three rabbits were formed with two control batches and one experimental batch. Each control lot is composed of three rabbits (male or female) while the experimental lot is composed of two males and one female. Each rabbit from the control lots was collected separately from the red tube (dry tube) and transported to the laboratory for analysis. The rabbits from the experimental batch were also collected separately a few minutes after the injection of Naja nigricollis venom for analysis of biochemical parameters. However, prior to these experiments, an in vitro hemolysis test of Naja nigricollis venom was performed on whole blood to verify the hemolysing power of Naja nigricollis venom. The results of this study reveal that:- the venom of Naja nigricollis has a dose-dependent hemolysing power in vitro and in vivo;- with a few exceptions, the biochemical parameters of males are generally higher than those of females;- the venom of Naja nigricollis causes kidney failure and cardiovascular disease in some animals, promotes a risk of coronary death and diabetes in others, causes neuromuscular and cardiac signs due to dyskalemia in others, and finally, a hepatocellular damage or disturbance of bile flow, a heart problem and vitamin B6 deficiency in one type of animal. - the venom of Naja nigricollis is fatal.